Hollow bone mineral-like calcium phosphate particles
AssigneeThe Trustees of the University of Pennsylvania
InventorsShulamith Radin, Paul Ducheyne, Sylvie Falaize, Portonovo S. Ayyaswamy
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Abstract
Hollow particles having a shell substantially composed of calcium-phosphate, methods for preparing the same, and methods of use are disclosed. The particles are obtained by differential immersion of silica-based, calcium and phosphate containing glass particles.
Claims29
A hollow particle having a shell, said shell comprising calcium-phosphate and having an outer diameter of up to about 5 mm.
A method for transforming silica-based glass particles into calcium-phosphate shells in vitro comprising immersing silica-based glass particles comprising silica in an aqueous solution undersaturated in soluble silica for a period sufficient to allow substantially all the silica to dissolve from said particles.
A method for filling a bone defect comprising implanting hollow particles having a shell comprising a carbonated, bone-mineral like, calcium-phosphate layer into said defect, said particles further having an outer diameter of up to about 5 mm.
Dependencies are inferred from the claim text.