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US 2002/0172689 A1Published application
Enhancement of oligomeric viral immunogenicity
AssigneeAlbany Medical College
InventorMark D. Scott
Life of this patent
Estimating the term…
Abstract
A method and structure for forming a viral-physiological structure. A naked virus having a capsid is provided. A linker molecule having a covalently attached polymer is covalently bonded to the capsid to form a polymer-protected virus. An immunogenicity of the polymer-protected virus with respect to an animal exceeds an immunogenicity of the naked virus with respect to the animal.
Claims69
A method for forming a viral-physiological structure, comprising:
- providing a naked virus having a capsid;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to an animal exceeds an immunogenicity of the naked virus with respect to the animal.
A method for forming a viral-physiological structure, comprising:
- providing a naked virus having a capsid;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein the polymer has a long chain length that causes an immunogenicity of the polymer-protected virus with respect to a given animal to exceed an immunogenicity of the naked virus with respect to the given animal.
A method for forming a viral-physiological structure, comprising:
- providing a naked virus having a capsid;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein a camouflaging of a charge site at the capsid by the polymer causes an immunogenicity of the polymer-protected virus with respect to a given animal to exceed an immunogenicity of the virus with respect to the given animal.
A method for forming a viral-physiological structure, comprising:
- providing a naked virus having a capsid;
- providing an animal;
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- and
- introducing the polymer-protected virus into the animal.
2 more elements
A method for forming a viral-physiological structure, comprising:
- providing a naked virus having a capsid;
- providing an animal;
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- and
- introducing a quantity of the polymer-protected virus into the animal, wherein said quantity is sufficient to evoke an immune response by the animal to the virus.
2 more elements
A method for forming a viral-physiological structure, comprising:
- providing a naked virus having a capsid;
- providing an animal;
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- and
- introducing a quantity of the polymer-protected virus into the animal, wherein said quantity is sufficient to immunize the animal against infection by the virus.
2 more elements
A method for forming a viral-physiological structure, comprising:
- providing a naked virus having a capsid;
- providing an animal;
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- introducing a quantity of the polymer-protected virus into the animal, wherein said quantity is sufficient to immunize the animal against infection by the virus;
- and
- immunizing the animal against infection by the virus as a consequence of the polymer-protected virus so introduced into the animal.
3 more elements
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- and
- means for covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to an animal exceeds an immunogenicity of the naked virus with respect to the animal.
A method for forming a viral-physiological structure, comprising:
- a naked virus having a capsid;
- and
- means for covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein the polymer has a long chain length that causes an immunogenicity of the polymer-protected virus with respect to a given animal to exceed an immunogenicity of the virus with respect to the given animal.
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- and
- means for covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein a camouflaging of a charge site at the capsid by the polymer causes an immunogenicity of the polymer-protected virus with respect to a given animal to exceed an immunogenicity of the virus with respect to the given animal.
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- an animal;
- means for covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- and
- means for introducing the polymer-protected virus into the animal.
2 more elements
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- an animal;
- means for covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- and
- means for introducing a quantity of the polymer-protected virus into the animal, wherein said quantity is sufficient to evoke an immune response by the animal to the virus.
2 more elements
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- an animal;
- means for covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- and
- means for introducing a quantity of the polymer-protected virus into the animal, wherein said quantity is sufficient to immunize the animal against infection by the virus.
2 more elements
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- an animal;
- means for covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- means for introducing a quantity of the polymer-protected virus into the animal, wherein said quantity is sufficient to immunize the animal against infection by the virus;
- and
- means for immunizing the animal against infection by the virus as a consequence of the polymer-protected virus so introduced into the animal.
3 more elements
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to an animal exceeds an immunogenicity of the naked virus with respect to the animal.
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein the polymer has a long chain length that causes an immunogenicity of the polymer-protected virus with respect to a given animal to exceed an immunogenicity of the virus with respect to the given animal.
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein a camouflaging of a charge site at the capsid by the polymer causes an immunogenicity of the polymer-protected virus with respect to a given animal to exceed an immunogenicity of the virus with respect to the given animal.
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- an animal;
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- and
- the polymer-protected virus within the animal.
2 more elements
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- an animal;
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- and
- a quantity of the polymer-protected virus within the animal, wherein said quantity is sufficient to evoke an immune response by the animal to the virus.
2 more elements
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- an animal;
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- and
- a quantity of the polymer-protected virus within the animal, wherein said quantity is sufficient to immunize the animal against infection by the virus.
2 more elements
A viral-physiological structure, comprising:
- a naked virus having a capsid;
- an animal;
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to the animal exceeds an immunogenicity of the naked virus with respect to the animal;
- and
- a quantity of the polymer-protected virus within the animal, wherein a portion of said quantity is virally fragmented, wherein the animal has produced antibodies against the virus so introduced, and wherein the antibodies so produced are sufficient to immunize the animal against infection by the virus.
2 more elements
Dependencies are inferred from the claim text.