Methods and compositions for therapeutic intervention in infectious disease
OwnerGraham Stewart, Peadar O'Gaora +1inventors
InventorsGraham Stewart, Peadar O'Gaora, Douglas Young
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Abstract
Methods and compositions for the treatment and prevention of infectious diseases are provided. In particular, efficient vaccines comprising genetically modified pathogens are provided. The vaccines generally comprise mycobacterial mutants having modified protein production capabilities. In one embodiment, the mutants overexpress heat shock protein. In a specific embodiment, the mycobacterial mutant overexpresses heat shock proteins 60 and/or 70. Also provided are modified BCG vaccines capable of overexpressing heat shock proteins 60 and/or 70.
Claims20
An immunogenic composition comprising mycobacteria wherein said mycobacteria comprises modified protein production.
A method for eliciting an immune response in a human or animal comprising to said human or animal an immunogenic composition wherein said composition comprises an pathogenic organism having modified heat shock protein production.
A method for treating mycobacterial disease comprising administering to a human or animal an immunogenic composition comprising modified mycobacterial pathogens wherein said mycobacterial pathogens have increased heat shock protein production.
An immunogenic composition comprising an improved BCG vaccine wherein the vaccine comprises modified M. bovis having increased heat shock protein production.
Dependencies are inferred from the claim text.