Diagnosis of metastatic cancer by the mts-1 gene
OwnerEugene Lukanidininventor
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Abstract
The present invention is directed towards the diagnosis of malignant cancer by detection of the mts-1 MRNA or the mts-1 protein, encoded by the mts-1 gene. The present invention contemplates the use of recombinant mts-1 DNA and antibodie4 directed against the mts-1 protein to diagnose the metastatic potential of several types of tumor cells, including, for example, thyroid, epithelial, lung, liver and kidney tumor cells. The present invention is also directed to mammalian cell lines and tumors with high and low metastatic potential which have been developed to serve as useful model systems for in vitro and in vivo anti-metastasis drug screening.
Claims10
A method of treatment of cancer comprising therapeutically administering a reagent directed against the mts-1 protein.
A method of treatment of cancer comprising therapeutically administering an oligonucleotide capable of binding to an mts-1 MRNA.
A method of inactivating, destroying, or nullifying an mts-1 protein or cells expressing the mts1 protein comprising directing antibodies against said mts-1 protein.
A method of inhibiting metastasis in a cancerous cell which comprises providing to said cancerous cell a nucleic acid encoding an antisense mts1 nucleotide sequence.
A method of inhibiting metastasis in a cancerous cell which comprises providing to said cancerous cell an expression vector comprising a nucleic acid encoding an antisense nucleotide sequence for a mammalian mts-I operably linked to a segment of said vector which can effect expression of an antisense mts-1 RNA.
Dependencies are inferred from the claim text.