Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies
AssigneeNational Jewish Health
InventorsMichael F. Lahn, Willi K. Born, Arihiko Kanehiro, Erwin Gelfand
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Abstract
Disclosed is a method to reduce airway hyperresponsivesness in an animal by the direct delivery to the lungs of aerosolized antibodies against T cell receptors. The method is particularly useful for treating airway hyperresponsiveness associated with allergic inflammation, is effective at extremely low doses of antibody, and does not have a substantial effect on the peripheral immune system.
Claims35
A method to reduce airway hyperresponsiveness in a mammal that has, or is at risk of developing, airway hyperresponsiveness, comprising administering to the lungs of said mammal an aerosolized antibody formulation comprising antibodies that selectively bind to a receptor on a T cell.
Dependencies are inferred from the claim text.