Human interferon-epsilon: a type I interferon
AssigneeGenentech, Inc.
InventorsJian Chen, Paul Godowski, William I. Wood, Dong-Xiao Zhang
Life of this patent
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Abstract
The invention concerns a novel human interferon-ε, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-α family and from IFNs-β and -γ. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production are also included.
Claims26
Isolated nucleic acid comprising DNA having at least a 95% sequence identity to (a) a DNA molecule encoding a novel human interferon-ε polypeptide (designated PRO655) comprising the sequence of amino acids from about 22 to 189 of FIG. 1 (SEQ ID NO:1), or (b) the complement of the DNA molecule of (a).
An isolated nucleic acid comprising DNA having at least a 95% sequence identity to (a) a DNA molecule encoding the same mature polypeptide encoded by the human interferon cDNA in ATCC Deposit No. 209509 (DNA50960-1224), or (b) the complement of the DNA molecule of (a).
An isolated nucleic acid comprising DNA hybridizing under high stringency conditions to the complement of a DNA molecule having SEQ ID NO:
- 2.
An isolated polypeptide comprising a sequence having at least 95% amino acid sequence identity with the sequence of amino acids from about 22 to 189 of FIG. 1 (SEQ ID NO:1).
An isolated polypeptide comprising a polypeptide encoded by nucleic acid hybridizing under high stringency conditions to the complement of nucleic acid having the sequence of SEQ ID NO:
- 2.
Isolated native sequence IFN-ε polypeptide comprising amino acid residues 22 to 208 of FIG. 1 (SEQ ID NO:1).
A chimeric molecule comprising an IFN-ε polypeptide fused to a heterologous amino acid sequence.
An antibody which specifically binds to an IFN-ε polypeptide.
A composition comprising an effective amount of an IFN-ε polypeptide or an agonist thereof, in admixture with a pharmaceutically acceptable carrier.
A method for inhibiting the growth of a tumor cell comprising exposing the cell to an effective amount of an IFN-ε polypeptide or an agonist thereof.
A method for treating viral infection comprising administering a therapeutically effective amount of an IFN-ε polypeptide or an agonist thereof.
A method for upregulation of the immune system comprising administering a therapeutically effective amount of an IFN-ε polypeptide or an agonist thereof.
An article of manufacture, comprising:
- a container;
- and
- a composition comprising an active ingredient contained within the container;
- wherein the composition is effective for inhibiting neoplastic cell growth and/or to cause apoptosis, and the active agent is an IFN-ε polypeptide or an agonist thereof.
Dependencies are inferred from the claim text.