Process for the purification of water-soluble non-ionic contrast agents
AssigneeIndustrial Technology Research Institute
InventorsShin-Shin Wang, Hui-Ping Tsai, Chii-Chang Lai
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Abstract
A process for the purification of water-soluble non-ionic contrast agents from water-soluble non-ionic impurities involves the steps of (a) injecting a raw water-soluble non-ionic contrast agent solution on a chromatographic column containing non-ionic resins; (b) eluting water-soluble impurities contained in the raw water-soluble non-ionic contrast agent solution with deionized water as a first eluent, and (c) eluting a water-soluble non-ionic contrast agent with alcohol as a second eluent.
Claims5
A process for the purification of water-soluble non-ionic contrast agents from water-soluble non-ionic impurities, which comprise polar aprotic solvents, inorganic salts and by-products, involves the steps of:
- (a) injecting a raw water-soluble non-ionic contrast agent solution on a chromatographic column containing non-ionic resins;
- (b) eluting water-soluble impurities contained in the raw water-soluble non-ionic contrast agent solution with deionized water as a first eluent;
- and
- (c) eluting a water-soluble non-ionic contrast agent with alcohol as a second eluent.
Dependencies are inferred from the claim text.