Mammalian CDP-diacylglycerol synthase
AssigneeCell Therapeutics, Inc.
InventorDavid W. Leung
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Abstract
There is disclosed cDNA sequences and polypeptides having the enzyme CDP-diacylglycerol synthase (CDS) activity. CDS is also known as CTP:phosphatidate cytidylyltransferase. There is further disclosed methods for isolation and production of polypeptides involved in phosphatidic acid metabolism and signaling in mammalian cells, in particular, the production of purified forms of CDS.
Claims16
An isolated polynucleotide, comprising a polynucleotide sequence selected from the group consisting of:
- (a) the DNA sequence of FIG. 8 and biologically active fragments thereof;
- and
- (b) a DNA sequence which encodes the polypeptide of FIG. 8 and biologically active fragments thereof;
- wherein said polynucleotide encodes a polypeptide having CDP-diacylglycerol synthase (CDS) activity.
An isolated polypeptide, comprising the amino acid sequence of FIG. 8 and biologically active fragments thereof, wherein said polypeptide has CDS activity.
An isolated polypeptide, comprising an amino acid sequence having 85 percent sequence identity to the amino acid sequence of FIG. 8, wherein said polypeptide has CDS activity.
Dependencies are inferred from the claim text.