LKB1 gene knockout animals
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsJun-Ichi Nezu, Asuka Ose, Kou-Ichi Jishage, Dieter E. Jenne
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Abstract
A mammal is provided, in which the LKB1 gene can be deleted phase-specifically and tissue-specifically. These mammals are highly useful as tools to reveal the onset mechanism for diseases caused by LKB1 gene deficiency, such as Peutz-Jeghers syndrome and cancers, as well as to develop therapeutic agents, methods, and so on for the diseases.
Claims54
A transgenic, non-human mammal in which the suppression of expression of an endogenous LKB1 gene can be induced.
A transgenic, non-human mammal wherein the expression of an endogenous LKB1 gene is inducibly suppressed.
A transgenic, non-human mammalian cell, in which suppression of the expression of an LKB1 gene can be induced and wherein the cell can be differentiated into an individual mammal.
A transgenic, non-human mammalian cell, in which the expression of an LKB1 gene is inducibly suppressed and wherein the cell can be differentiated into an individual mammal.
Dependencies are inferred from the claim text.