Resorbable bone replacement and bone formation material
AssigneeCurasan AG
InventorsHelmut Heide, Joachim Pabst, Albrecht Dinkelaker, Olaf Pobantz
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Abstract
The invention relates to a resorbable bone replacement and bone formation material (augmentation material) based on porous β-tricalcium phosphate (β-TCP).
Claims19
Resorbable bone replacement and bone formation material (augmentation material) based on porous β-tricalcium phosphate (β-TCP), which can be produced by
- (a) baking a phosphate powder of a chemical composition the residue on baking of which yields theoretically chemically pure tricalcium phosphate and
- (b) providing the baked blanks with tubular pores, characterised in that
- β-tricalcium phosphate (β-TCP) is baked at least twice and especially at least three times and the formation of the thermodynamically stable adjacent phases of β-TCP is prevented by
- (i) powdering the presynthesis product obtained according to step (a),
- (ii) optionally baking the powdered presynthesis product together with phosphate powder according to step (a) and powdering the material obtained and optionally repeating step (ii) once or more than once,
- (iii) compressing the powdered product obtained in step (i) or step (ii) together with phosphate powder according to step (a) to form blanks and subjecting the blanks formed to final ceramic baking and
- (iv) subjecting the compressed or baked blanks, at least 99.5% of which consists of pure β-tricalcium phosphate (β-TCP), to step (b).
Formation material according to one of the preceding claims, which can be produced by
- (i) starting from a presynthesis product obtainable by baking a phosphate powder of a chemical composition the residue on baking of which yields theoretically chemically pure tricalcium phosphate as a presynthesis product, and powdering that presynthesis product,
- (ii) optionally baking the powdered presynthesis product together with phosphate powder according to step (i) and powdering the material obtained and optionally repeating step (ii) once or more than once,
- (iii) compressing the powdered product obtained in step (i) or step (ii) together with phosphate powder according to step (i) to form blanks and subjecting the blanks formed to final ceramic baking and
- (iv) providing the compressed or baked blanks with tubular pores.
Formation material according to one of claims 1, 3 or 5, obtainable by using in step (ii) and/or step (iii) from 1 to 50% by weight, especially from 1 to 25% by weight, phosphate powder (based on the total weight of phosphate powder and already baked material).
Formation material according to one of the preceding claims, characterised in that the sintered structure has a uniform, interconnected microporosity having pore widths in the region of from 2 to 15 μm and especially from 4 to 10 μm and/or the matrix of the augmentation material is tightly sintered to microporosity, especially with microparticles that are loosely bound in the sintered structure and/or phagocytosable, having a diameter of max. 15 μm, being absent.
Formation material according to one of the preceding claims, characterised by a microporosity of 20% by volume or more, preferably from 20 to 40% by volume, and especially 30% by volume or more, based on the overall porosity (consisting of micro- and macro-porosity).
Formation material according to one of the preceding claims, obtainable by providing the compressed blank with tubular pores with the aid of a compression mould of optionally more than one part.
Formation material according to one of the preceding claims, obtainable by providing the baked blank with tubular pores by means of milling or drilling.
Formation material according to one of the preceding claims, characterised in that the formation material is in block form, with 2- or 3-dimensionally oriented macroscopic tubular pores passing through each block, which are in each case arranged perpendicular to the block surface or to an imaginary plane laid through the block or against the block and form an interconnecting system of tubular pores.
Formation material according to one of the preceding claims, characterised by tubular pores that have radii in the region of from 100 to 2000 μm and especially from 500 to 2000 μm.
Formation material according to one of the preceding claims, characterised in that the formation material, present in block form, is penetrated by the tubular pores spaced apart at a defined spacing with respect to one another, especially at a spacing that corresponds to a wall thickness of not more than from 1500 to 4000 μm and especially from 2000 to 3000 μm.
Formation material according to one of the preceding claims, characterised by an overall porosity (consisting of micro- and macro-porosity) of more than 50% by volume.
Formation material according to one of the preceding claims, characterised by a macroporosity of from 25 to 50% by volume, and especially from 30 to 40% by volume, based on the overall porosity (consisting of micro- and macro-porosity.
Formation material according to one of the preceding claims, characterised in that the block form is a simple geometric shape, especially that of a cube, cuboid, taper, cone or disc.
Formation material according to one of the preceding claims, characterised in that it is a semi-finished product, especially for subsequent mechanical processing, preferably for individual adaptation in the case of a bone defect in mouth or jaw medicine, orthopaedic surgery or trauma surgery.
Dependencies are inferred from the claim text.