Local drug delivery devices and methods for maintaining the drug coatings thereon
AssigneeCordis Corporation
InventorsGerard H. Llanos, David Christian Lentz
Life of this patent
Estimating the term…
Abstract
Local drug delivery medical devices are utilized to deliver therapeutic dosages of drugs, agents or compounds directly to the site where needed. The local drug delivery medical devices utilize various materials and coating methodologies to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
Claims51
A local drug delivery apparatus comprising:
- a medical device for implantation into a treatment site of a living organism;
- at least one agent in therapeutic dosages releasably affixed to the medical device for the treatment of reactions by the living organism caused by the medical device or the implantation thereof;
- and
- a material for preventing the at least one agent from separating from the medical device prior to implantation of the medical device at the treatment site, the material being affixed to at least one of the medical device or a delivery system for the medical device.
A local drug delivery apparatus comprising:
- a medical device for implantation into a treatment site of a living organism;
- at least one agent in therapeutic dosages releasably affixed to the medical device for the treatment of reactions by the living organism caused by the medical device or the implantation thereof, the at least one agent being incorporated into a polymeric matrix;
- and
- a material for preventing the at least one agent from separating from the medical device prior to implantation of the medical device at the treatment site, the material being affixed to at least one of the medical device or a delivery system for the medical device.
A local drug delivery apparatus comprising:
- a medical device for implantation into a treatment site of a living organism;
- at least one agent in therapeutic dosages releasably affixed to the medical device for the treatment of reactions by the living organism caused by the medical device or the implantation thereof, the at least one agent being incorporated into a polymeric matrix;
- and
- a material for preventing the polymeric matrix from adhering to itself when parts of the medical device make contact with one another.
A drug delivery device comprising:
- a medical device for implantation into a treatment site of a living organism;
- and
- therapeutic dosages of one or more anti-proliferatives, one or more anti-inflammatories, one or more anti-coagulants, and one or more immunosuppressants releasably affixed to the medical device for the treatment of reactions by the living organism caused by the medical device or the implantation of the medical device at the treatment site.
38 The drug delivery device according to claim 37, wherein the material for preventing the therapeutic dosages releasably affixed to the medical device from separating from the medical device comprises a lubricious coating.
A method for maintaining agents on a medical device during implantation into a treatment site of a living organism comprising:
- releasably affixing one or more agents in therapeutic dosages to the medical device;
- treating one of the medical device or the delivery device with a material for preventing the one or more agents from separating from the medical device during delivery and implantation of the medical device at the treatment site;
- and
- loading the medical device into a delivery device.
A method for maintaining agents on a medical device during implantation into a treatment site of a living organism comprising:
- releasably affixing one or more agents in therapeutic dosages to the medical device by incorporating the one or more agents in at least one polymer;
- treating the medical device with a material for preventing the polymer from adhering to itself when parts of the medical device make contact;
- and
- loading the medical device into a delivery device.
A method for maintaining agents on a medical device during implantation into a treatment site of a living organism comprising:
- coating at least a portion of the medical device with a primer layer;
- coating the primer layer with a first polymer layer including cross-linking moieties;
- cross-linking the first polymer layer to the primer layer;
- and
- releasably affixing one or more agents in therapeutic dosages to the medical device by incorporating the one or more agents in at least one polymer, the polymer being similar in chemical composition to the first polymer.
Dependencies are inferred from the claim text.