Apparatus and method of photodynamic eradication of organisms utilizing pyrrolnitrin
AssigneeMerrill A. Biel
InventorMerrill A. Biel
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Abstract
The invention relates to a method of photoeradication of cellular and acellular organisms including the steps of providing a photosensitive material and pyrrolnitrin in association with a cellular or acellular organism and applying light in association with the cellular or acellular organism to cause a disruption of the organism. The method according to the present invention may be utilized in invitro and invivo treatment protocols for infections, sterilization procedures, cancer cell eradication, virus and fungus eradication, spore eradication, and biofilm organism eradication. Additional aspects of the invention include particular combinations of photosensitive materials, pyrrolnitrin, and optional surfactants for use in photodynamic therapies.
Claims55
A method of photoeradication of cells comprising the steps of:
- identifying an area of cell activity;
- providing pyrrolnitrin and a photosensitive material to the area of cell activity;
- and
- exposing the area of cell activity to a light having a light wavelength, light dosage and a light dosage rate to cause disruption of the cells.
A photodynamic therapy treatment kit comprising:
- a volume of a concentration including a combination of pyrrolnitrin and a photosensitive material;
- and
- a light emitting treatment device configured to emit light.
A method of treatment comprising:
- providing one or more cells;
- providing a concentration in proximity to the one or more cells, said concentration including a combination of pyrrolnitrin and a photosensitive material;
- and
- applying a light in proximity to the one or more cells, wherein the combination of the light and the pyrrolnitrin and the photosensitive material causes disruption of the one or more cells.
A method of photodynamic disruption of acellular organisms comprising the steps of:
- identifying an area of acellular organism activity;
- applying a concentration including a combination of pyrrolnitrin and a photosensitive material to the area of acellular organism activity;
- and
- exposing the area of acellular organism activity to light having a light wavelength, light dosage and a light dosage rate.
A treatment protocol for a living body having cancer cells, said protocol comprising the steps of:
- identifying cancer cells within the living body;
- administering pyrrolnitrin to the living body;
- administering a photosensitive material to the living body;
- and
- applying a light in proximity to the cancer cells, the combination of photosensitive material and light resulting in disruption of the cancer cells.
A method of cell disruption for use in an air filtration device, said method comprising:
- providing a plurality of cells upon an air filtration substrate;
- disposing a pyrrolnitrin-containing material in proximity to the plurality of cells;
- disposing a photosensitive material in proximity to the plurality of cells;
- and
- applying a light in proximity to the one or more cells to cause disruption of the plurality of cells.
A method of photodynamic eradication of organisms within a biofilm of a medical device, said method comprising the steps of:
- providing a photosensitive material and pyrrolnitrin to a surface of the medical device supporting a biofilm;
- providing a source of light illumination having predetermined light characteristics;
- and
- illuminating the biofilm layer with the light source to achieve a photodynamic eradication of organisms within the biofilm layer.
Dependencies are inferred from the claim text.