Closed-loop neuromodulation for prevention and treatment of cardiac conditions
AssigneeMedtronic, Inc.
InventorsMichael R.S. Hill, Gary W. King, Thomas J. Mullen, Xiaohong Zhou
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Abstract
A method and apparatus to provide therapy to a patient for protecting cardiac tissue from insult is disclosed. The method comprises delivering electrical stimulation to one or more predetermined portions of the nervous system in a patient's body; and monitoring one or more physiologic indices of the body to determine whether the delivered therapy is effective. That is, a closed-loop feedback controller is used to apply electrical stimulation to preselected regions of the patient's body, and then the physiologic response of the patient is monitored to determine the efficacy of the stimulation.
Claims36
A method for providing stimulation in anticipation of an insult to cardiac tissue, comprising:
- delivering electrical stimulation to one or more predetermined portions of the nervous system in a patient's body;
- and
- monitoring one or more physiologic indices of the body to determine whether the delivered therapy is effective.
A system to control delivery of electrical stimulation to one or more nerves in a body, comprising:
- a sensing circuit to sense at least one physiologic parameter;
- a stimulation circuit to provide the electrical stimulation to the one or more nerves;
- and
- a control circuit coupled to the sensing circuit and to the stimulation circuit to control the stimulation circuit based on anticipation of an occurrence of a cardiac insult as indicated by the at least one physiologic parameter.
A device to provide electrical stimulation to at least one predetermined portion of the nervous system in a patient's body, comprising:
- means for sensing at least one physiologic indication in the patient's body;
- means for providing stimulation to the at least one predetermined portion of the nervous system in the patient's body;
- and
- means for controlling the stimulation means to provide the stimulation based on an indication of a probable future cardiac insult as determined by the at least one physiologic indication in the patient's body.
An apparatus for protecting cardiac tissue from insult, comprising:
- at least one electrode positionable at a region adjacent a patient's nervous tissue;
- a sensing circuit to detect at least one physiologic parameter;
- and
- a controller adapted to deliver electrical stimulation to the at least one electrode for a period of time prior to onset of an insult, wherein at least one parameter of the electrical stimulation is controlled as a function of the sensed physiologic parameter.
Dependencies are inferred from the claim text.