Combination x-ray radiation and drug delivery devices and methods for inhibiting hyperplasia
AssigneeXoft microTube, Inc.
InventorMichael R. Forman
Life of this patent
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Abstract
The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled drug delivery in combination with x-ray radiation delivery to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and agent delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an x-ray tube coupleable to the catheter body for applying a radiation dose to a body lumen, and means coupleable to the catheter body for releasing an agent to the body lumen.
Claims43
A combined radiation and agent delivery catheter for inhibiting hyperplasia, comprising:
- a catheter body having a proximal end and a distal end;
- an x-ray tube coupleable to the catheter body for applying a radiation dose to a body lumen;
- and
- means coupleable to the catheter body for releasing an agent to the body lumen.
A combined radiation and agent delivery catheter for inhibiting hyperplasia, comprising:
- a catheter body having a proximal end, a distal end, and an infusion lumen for releasing an agent;
- a pair of axially spaced apart balloons on the catheter body;
- and
- an x-ray tube coupleable to the catheter body for applying a radiation dose between the axially spaced apart balloons.
A combined radiation and agent delivery device for inhibiting hyperplasia, comprising:
- a catheter body having a proximal end and a distal end;
- an x-ray tube coupleable to the catheter body for applying a radiation dose to a body lumen;
- a stent releasable from the catheter body, wherein the x-ray tube may be positioned within the catheter body to deliver radiation to a vascular region where the stent has been released;
- and
- a source of an agent on the stent, wherein the agent is released from the stent after the stent has been implanted in the body lumen.
A method for inhibiting hyperplasia in a body lumen, said method comprising:
- releasing an anti-hyperplasia agent at a target region within the body lumen;
- and
- directing x-ray radiation at the target region, wherein the agent and the x-ray radiation combine to inhibit hyperplasia.
A method for inhibiting hyperplasia in a body lumen, said method comprising:
- positioning an x-ray tube at a target region in the body lumen;
- positioning a stent at the target region in the body lumen;
- applying an x-ray radiation dose to the target region;
- and
- releasing an agent from the stent to the target region.
Dependencies are inferred from the claim text.