High affinity humanized anti-CEA monoclonal antibodies
OwnerW. H. Kerr Anderson, Philip R. Tempest +3inventors
InventorsW. H. Kerr Anderson, Philip R. Tempest, Frank J. Carr, William J. Harris, Kathryn Armour
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Abstract
Novel humanized monoclonal antibodies, fragments or derivatives thereof which specifically bind carcinoembryonic antigen (CEA) are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express CEA as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express CEA.
Claims24
A humanized antibody or humanized antibody fragment which specifically binds CEA wherein said humanized antibody or humanized antibody fragment is derived from a murine antibody that binds CEA.
Dependencies are inferred from the claim text.