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US 2002/0165360 A1Published application
Chimeric effector cell receptors against carcinoembryonic antigen
OwnerRichard P. Junghansinventor
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Abstract
This invention relates to a specific humanized antibody against carcinoembryonic antigen (CEA) called hMN14 when prepared as a chimeric molecule with signaling molecules of T cells and other effector cells, and the use thereof in the treatment of cancers expressing CEA.
Claims6
A chimeric molecule comprised of the CEA binding domain of humanized antibody MN14 as a single chain antibody with a (GGSGS)3 linker, the zeta signaling chain of the T cell receptor and an intervening CD8α hinge in which the cysteine residues have been mutated, with the sequence of FIG. 3.
Dependencies are inferred from the claim text.