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US 2002/0165352 A1Published application
Protein-protein interactions
AssigneeMyriad Genetics, Inc.
InventorsDaniel M. Cimbora, Karen Heichman, Paul L. Bartel
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AssigneeMyriad Genetics, Inc.
InventorsDaniel M. Cimbora, Karen Heichman, Paul L. Bartel
Estimating the term…
The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitis (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.
An isolated protein complex comprising two proteins, the protein complex selected from the group consisting of:
An isolated nucleic acid encoding a protein selected from the group consisting of a protein comprising an amino acid sequence set forth in SEQ ID NO:4 and a protein comprising an amino acid sequence set forth in SEQ ID NO:6.
An isolated nucleic acid encoding a protein selected from the group consisting of (a) a protein comprising an amino acid sequence which is at least 70% identical to the amino acid sequence set forth in SEQ ID NO:4 and which is capable of interacting with ER-alpha and (b) a protein comprising an amino acid sequence which is at least 70% identical to the amino acid sequence set forth in SEQ ID NO:6 and which is capable of interacting with ER-beta.
An isolated nucleic acid comprising a nucleotide sequence which is at least 60% identical to a nucleic acid selected from the group consisting of a nucleic acid comprising nucleotides 1-528 of SEQ ID NO:3 or complement thereof and a nucleic acid comprising nucleotides 1-654 of SEQ ID NO:5.
An isolated nucleic acid selected from the group consisting of (a) a nucleic acid comprising a nucleotide sequence set forth in SEQ ID NO:3 or complement thereof and (b) a nucleic acid comprising a nucleotide sequence set forth in SEQ ID NO:5.
An isolated nucleic acid comprising at least 21 nucleotides that encodes a contiguous span of at least 7 amino acids of a protein selected from the group consisting of a protein comprising an amino acid sequence set forth in SEQ ID NO:4 and a protein comprising an amino acid sequence set forth in SEQ ID NO:6.
An isolated polypeptide selected from the group consisting of a polypeptide comprising an amino acid sequence set forth in SEQ ID NO:4 and a polypeptide comprising an amino acid sequence set forth in SEQ ID NO:6.
An isolated polypeptide selected from the group consisting of (a) a polypeptide comprising an amino acid sequence that is at least 70% identical to the amino acid sequence set forth in SEQ ID NO:4 and capable of interacting with ER-alpha and (b) a polypeptide comprising an amino acid sequence that is at least 70% identical to the amino acid sequence set forth in SEQ ID NO:6 and capable of interacting with ER-beta.
An isolated polypeptide selected from the group consisting of (a) a polypeptide comprising an amino acid sequence of from 4 to 30 amino acids that is at least 75% identical to a contiguous span of amino acids of the amino acid sequence set forth in SEQ ID NO:4 of the same length, wherein said isolated polypeptide is capable of interacting with ER-alpha and (b) a polypeptide comprising an amino acid sequence of from 4 to 30 amino acids that is at least 75% identical to a contiguous span of amino acids of the amino acid sequence set forth in SEQ ID NO:6 of the same length, wherein said isolated polypeptide is capable of interacting with ER-beta.
A method for making an isolated polypeptide selected from the group consisting of a polypeptide comprising an amino acid sequence set forth in SEQ ID NO:4 and a polypeptide comprising an amino acid sequence set forth in SEQ ID NO:6, comprising:
Dependencies are inferred from the claim text.