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US 2002/0165343 A1Published application
Growth hormone secretagogues
AssigneeZentaris AG
InventorsJean Martinez, Jean-Alain Fehrentz, Vincent Guerlavais
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds of formula I 1 which are useful for elevating the plasma level of growth hormone in a mammal as well for the treatment of growth hormone secretion deficiency, growth retardation in child and metabolic disorders associated with growth hormone secretion deficiency.
Claims14
Compounds of the formula I
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- wherein * means a carbon atom which, when a chiral carbon atom, has a R or S configuration, one of R1 and R3 is an hydrogen atom and the other is a group of formula II
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- R2 is a hydrogen atom, a linear or branched C1-C6 alkyl group, an aryl group, a heterocyclic group, a cycloalkyl group, a (CH2)n-aryl group, a (CH2)n-heterocyclic group, a (CH2)n-cycloalkly group, a methylsulfonyl group, a phenylsulfonyl group, a C(O)R8 group or a group according to one of formulas III to VIII:
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- R4 is a hydrogen atom or a linear or branched C1-C4-alkyl group, R5 is a hydrogen atom, a linear or branched C1-C4 alkyl group, a (CH2)n-aryl group, a (CH2)n-heterocyclic group, a (CH2)n-cycloalkyl group or an amino group, R6 and R7 are independently from each other a hydrogen atom or a linear or branched C1-C4-alkyl group, R8 is a linear or branched C1-C6-alkyl group, R9, R10, R11, R12, R13, R14, R15, and R16 are independently from each other a hydrogen atom or a linear or branched C1-C4-alkyl group, m is 0, 1 or 2 and n is 1 or 2.
4 more elements
A compound which is
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A compound which is
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A compound which is
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Dependencies are inferred from the claim text.