# US 2002/0165266 A1 · Use of oxandrolone in the treatment of burns and other wounds

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- Number: US 2002/0165266 A1
- Document ID: US20020165266A1
- Status: Published application
- Kind: A1
- Application number: 10/011,377
- Filed: 2001-10-22
- Published: 2002-11-07
- Earliest claimed: 1996-12-05
- Assignees: Bio-Technology General Corp.
- Inventors: Don Fishbein
- Web page: https://patentgrep.com/patent/US20020165266A1

## CPC

- A61K 31/366: having six-membered rings, e.g. delta-lactones
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The subject invention provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The invention also provides a method of treating a wound in a patient suffering from a wound which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The subject invention further provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone in conjunction with a protein supplement to the patient.

## Claims

### Claim 1

A method of treating a wound in a patient suffering from a wound which comprises administering a therapeutically effective amount of an oxandrolone to the patient.

### Claim 2

A method of improving the rate of healing of a wound in a patient suffering from a wound which comprises administering a therapeutically effective amount of an oxandrolone to the patient.

### Claim 3 (depends on 1, 2)

A method according to claims 1 or 2, wherein the wound is a burn wound.

### Claim 4 (depends on 1, 2)

A method according to claims 1 or 2, wherein the wound comprises an ulcer.

### Claim 5 (depends on 1, 2)

A method according to claims 1 or 2, wherein the wound comprises a skin graft.

### Claim 6 (depends on 1, 2)

A method according to claims 1 or 2 wherein the amount of the oxandrolone is about 1-100 mg per day.

### Claim 7 (depends on 6)

A method according to claim 6 wherein the amount of the oxandrolone is about 20 mg per day.

### Claim 8 (depends on 6)

A method according to claim 6 wherein the amount of the oxandrolone is about 80 mg per day.

### Claim 9 (depends on 1, 2)

A method according to claims 1 or 2 wherein the oxandrolone is administered orally.

### Claim 10 (depends on 1, 2)

A method according to claims 1 or 2 wherein the oxandrolone is administered topically.

### Claim 11 (depends on 1, 2)

A method according to claims 1 or 2 wherein the oxandrolone is injected.

### Claim 12 (depends on 1, 2)

A method according to claims 1 or 2 wherein the oxandrolone is in a solid dosage form.

### Claim 13 (depends on 1, 2)

A method according to claims 1 or 2 wherein the oxandrolone is in a liquid dosage form.

### Claim 14 (depends on 1, 2)

A method according to claims 1 or 2 wherein the oxandrolone is in a sustained-release formulation.

### Claim 15

A method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone to the patient.

### Claim 16

A method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone in conjunction with a protein supplement to the patient.

### Claim 17 (depends on 15, 16)

A method according to claims 15 or 16 wherein the amount of the oxandrolone is about 1-100 mg per day.

### Claim 18 (depends on 17)

A method according to claim 17 wherein the amount of the oxandrolone is about 20 mg per day.

### Claim 19 (depends on 17)

A method according to claim 17 wherein the amount of the oxandrolone is about 80 mg per day.

### Claim 20 (depends on 15, 16)

A method according to claims 15 or 16 wherein the oxandrolone is administered orally.

### Claim 21 (depends on 15, 16)

A method according to claims 15 or 16 wherein the oxandrolone is administered topically.

### Claim 22 (depends on 15, 16)

A method according to claims 15 or 16 wherein the oxandrolone is injected.

### Claim 23 (depends on 15, 16)

A method according to claims 15 or 16 wherein the oxandrolone is in a solid dosage form.

### Claim 24 (depends on 15, 16)

A method according to claims 15 or 16 wherein the oxandrolone is in a liquid dosage form.

### Claim 25 (depends on 15, 16)

A method according to claims 15 or 16 wherein the oxandrolone is in a sustained-release formulation.

### Claim 26

A composition for use in topical treatment of wounds which comprises an oxandrolone and a pharmaceutically acceptable carrier.

### Claim 27 (depends on 26)

A composition according to claim 26 wherein the wound is selected from the group consisting of a burn, an ulcer and a skin graft.

### Claim 28 (depends on 1, 2, 15, 16)

A method according to claims 1, 2, 15 or 16, wherein the oxandrolone is 17α-methyl-17β-hydroxy-2-oxa-5α-androstan-3-one.

### Claim 29 (depends on 4)

A method according to claim 4 wherein the ulcer is a decubitus ulcer.
