4-phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein

Tetrahydroquinolines of the general formula (I)

• 102
• in which
• A represents phenyl which is optionally substituted up to 2 times by identical or different substituents from the group consisting of halogen, trifluoromethyl and straight-chain or branched alkyl or alkoxy having in each case up to 3 carbon atoms,
• D represents a radical of the formula
• 103
• in which
• R5 and R6 together form a carbonyl group (═O), or
• R5 represents hydrogen and
• R6 represents halogen or hydroxyl, or
• R5 and R6 represent hydrogen,
• R7 and R8 are identical or different and represent phenyl, naphthyl, benzothiazolyl, quinolyl, pyrimidyl or pyridyl which are optionally substituted up to 4 times by identical or different substituents from the group consisting of halogen, trifluoromethyl, nitro, cyano, trifluoromethoxy, or by a radical of the formula —SO2—CH3 or —NR9R10,
• in which
• R9 and R10 are identical or different and represent hydrogen or straight-chain or branched alkyl having up to 3 carbon atoms,
• E represents cycloalkyl having 3 to 6 carbon atoms, or represents straight-chain or branched alkyl having up to 8 carbon atoms,
• R1 represents hydroxyl, and
• R2represents hydrogen or represents methyl,
• R3 and R4 are identical or different and represent straight-chain or branched alkyl having up to 3 carbon atoms, or
• R3 and R4 together form a spiro-linked alkyl chain having 2 to 4 carbon atoms,
• and their salts and N-oxides.