Nasal delivery of apomorphine
AssigneeNastech Pharmaceutical Company Inc.
InventorsRaja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Romeo, Anthony P. Sileno
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Abstract
Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility and/or stability.
Claims61
A method of ameliorating male erectile dysfunction in a mammal comprising nasally administering a therapeutically effective amount of a dopamine receptor agonist to said mammal before, during or after sexual activity which is sufficient to induce an erection without causing substantial intolerable adverse side effects to said mammal.
A pharmaceutical composition for treating male erectile dysfunction in a mammal comprising a therapeutically effective amount of a dopamine receptor agonist in combination with a nasal delivery system, wherein said pharmaceutical composition does not cause substantial intolerable adverse side effects in said mammal.
A nasally administered pharmaceutical composition comprising a therapeutically effective amount of a dopamine receptor agonist dispersed in a buffer to maintain its pH, a pharmaceutically acceptable thickening agent and a humectant, wherein sand nasally administered pharmaceutical composition does not cause substantial intolerable adverse side effects when administered to said mammal.
A method of treating male erectile dysfunction without causing substantial intolerable adverse side effects in a mammal comprising administering into a nasal cavity of said mammal a therapeutically effective dosage of a dopamine receptor agonist in combination with a nasal delivery system comprising a pharmaceutically acceptable buffer, a thickening agent and a humectant.
A method of administering a therapeutically effective amount of a dopamine receptor agonist to a mammal through a nasal membrane thereof comprising delivering to said nasal membrane a therapeutically effective amount of said dopamine receptor agonist which does not cause substantial intolerable adverse side effects in said mammal, wherein said dopamine receptor agonist is dispersed in a nasal delivery system comprising a pharmaceutically acceptable a buffer, a thickening agent and a humectant.
An intranasal dosage unit for treating impotency or erectile dysfunction in a mammal comprising an effective amount of a dopamine receptor agonist in combination with an intranasal carrier comprising a buffer, wherein said dosage unit does not cause substantial intolerable adverse side effects in said mammal and an erection is produced in said mammal within about 60 minutes of administering said dosage unit to a nasal mucosa of said mammal.
A nasally administered pharmaceutical composition for treating male erectile dysfunction in a mammal comprising a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its solubility.
A nasally administered pharmaceutical composition for treating male erectile dysfunction in a mammal comprising a therapeutically effective amount of a dopamine receptor agonist which has been dispersed in a system to improve its stability.
Dependencies are inferred from the claim text.