N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists

A compound having the formula (I):

• 312
• or pharmaceutically acceptable salts thereof, wherein
• NonAr is a nonaromatic 5-7 membered ring containing 1 or 2 nitrogen ring atoms or an aza bicyclo octane ring;
• HetAr is a 5 or 6 membered heteroaromatic ring containing 1-3 nitrogen ring atoms, or isoxazolyl, thiazolyl, thiadiazolyl, quinolinyl, quinazolinyl, purinyl, pteridinyl, benzimidazolyl, pyrrolopyrimidinyl, or imidazopyridinyl;
• HetAr is optionally substituted with 1 or 2 substituents, each substituent independently is C1-4alkyl, C1-4alkoxy, C2-4alkynyl, trifluoromethyl, hydroxy, hydroxyC1-4alkyl, fluoro, chloro, bromo, iodo, cyano, methylsulfanyl, cyclopropylethynyl-, phenylethynyl-, heteroarylethynyl-,—N(C0-4alkyl)(C0-4alkyl), nitro, (C1-2alkyl)(C1-2alkyl)NCH2—, (C1-2alkyl)HNCH2—, Si(CH3)3—C—, or NH2C(O)—;
• A is —C0-4alkyl-;
• B is aryl(CH2)0-3—O—C(O), heteroaryl(CH2)1-3—O—C(O)—, indanyl(CH2)0-3—O—C(O)—, aryl(CH2)1-3—C(O)—, aryl-cyclopropyl-C(O)—, heteroaryl-cyclopropyl-C(O)—, heteroaryl(CH2)1-3—C(O)—, aryl(CH2)1-3—, heteroaryl(CH2)1-3—, aryl(CH2)1-3—NH—C(O)—, aryl(CH2)1-3—NH—C(NCN)—, aryl(CH2)1-3—SO2—, heteroaryl(CH2)1-3—SO2—, wherein any of the aryl or heteroaryl is optionally substituted by 1-5 substituents, each substituent independently is C1-4alkyl, C3-6cycloalkyl, C1-4alkoxy, trifluoromethyl, bromo, fluoro, or chloro;
• and
• X is H, OH, F, C1-4alkyl, C1-4alkoxy, NH2, or X taken with an adjacent bond is ═O.