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US 2002/0165238 A1Published application
Methods for the preparation of mirtazapine intermediates
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsLeonid Metzger, Shlomit Wizel
Life of this patent
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Abstract
The preparation of 1-(3-carboxypyridyl-2)-4-methyl-2-phenylpiperazine dihydrate and other mirtazapine intermediates are described. These compounds are particularly useful in the preparation of mirtazapine.
Claims19
1-(3-carboxypyridyl-2)-4-methyl-2-phenylpiperazine dihydrate.
A process for preparing 1-(3-carboxypyridyl-2)-4-methyl-2-phenylpiperazine dihydrate comprising the steps of:
- heating a mixture of a basic salt solution of a 1-(3-carboxypyridyl-2)-4-methyl-2-phenylpiperazine and an organic liquid;
- and
- neutralizing the solution with an acid.
A process for preparing mirtazapine comprising converting 1-(3-carboxypyridyl-2)-4-methyl-2-phenylpiperazine dihydrate to mirtazapine.
Dependencies are inferred from the claim text.