Alkoxycarbonylamino benzoic acid or alkoxycarbonylamino tetrazolyl phenyl derivatives as IP antagonists

A compound comprising Formula I:

• 36
• wherein:
• G1 is selected from the group consisting of a, b1, and b2
• 37
• A is selected from the group consisting of phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, and thienyl, all optionally substituted with lower alkyl, halogen, haloalkyl, alkoxy, cyano, nitro, —SO2R′, —NR′SO2R″, —SO2NR′R″, —NR′R″, or —COR′;
• R′ and R″ are each independently hydrogen or lower alkyl;
• G2 is selected from the group represented by the Formula c, d, e, and f
• 38
• R1 and R2 are independently in each occurrence selected from the group consisting of hydrogen, lower alkyl, halogen, haloalkyl, —NR′R″, —OR′, —NR′SO2R″, —SO2R′, —SO2NR′R″, —COR′, cyano, nitro, phenyl (optionally substituted with halogen, alkyl, cyano, nitro, or alkoxy), or heteroaryl (optionally substituted with halogen, alkyl, cyano, nitro or alkoxy);
• and wherein R′ and R″ are as defined hereinbefore;
• R1 and R2, if adjacent, taken together with the carbons to which they are attached may also form an aromatic ring, optionally substituted with one or two substitutents selected from the group consisting of lower alkyl, halogen, cyano, and lower alkoxy;
• and
• n is an integer selected from 0, 1, 2, and 3;
• or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof.