Back to results
US 2002/0165224 A1Published application
Use of y-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism
AssigneeLaboratorio Farmaceutico C.T. S.r.l.
InventorsRoberto Cacciaglia, Antonella Loche, Vincenzo Perlini, Lorenza Guano
Life of this patent
Estimating the term…
Abstract
Gamma-hydroxybutryic acid amides are used in the treatment of drug addiction and especially in the treatment of alcoholism.
Claims33
Use of amides of γ-hydroxybutyric acid (GHB) of formula (I)
- 9
- where R1 is a mono- or polycyclic aromatic group, containing one or more carbocyclic or heterocyclic aromatic rings or mixtures thereof, having 5 to 7 atoms in the ring, said rings being optionally substituted with one or more groups selected from the group consisting of C1-C8 alkyl, C1-C8 alkoxyl, aminic, C1-C8 mono-or dialkylaminic groups, and halogen, where said C1-C8 alkyl and C1-C8 alkoxyl groups may contain or be substituted with one or more double or triple bonds, or with one or more halogen groups
- R2 is selected from the group consisting of H;
- a linear or branched C1-C6 alkyl;
- a linear or branched C1-C6 alkyl substituted with one or more double or triple bonds, or with one or more aromatic groups;
- Q is selected from the group consisting of H and a linear or branched alkyl having 1 to 6 carbon atoms;
- n is an integer from 1 to 4;
- T1 and T2, individually, are selected from the group consisting of H and a linear or branched alkyl radical having 1 to 6 carbon atoms, in the treatment of drug addictions:
5 more elements
Amide of formula (I)
- 11
- selected from:
- amides of formula (I) where
- R1 is a mono- or polycyclic aromatic group, containing one or more carbocyclic or heterocyclic aromatic rings or mixtures thereof, having 5 to 7 atoms in the ring, said rings being optionally substituted with one or more groups selected from the group consisting of C1-C8 alkyl, C1-C8 alkoxyl, aminic, C1-C8 mono-or dialkylaminic groups, and halogen, where said C1-C8 alkyl and C1-C8 alkoxyl groups may contain or be substituted with one or more double or triple bonds, or with one or more halogen groups;
- Q is selected from the group consisting of H and a linear or branched alkyl having 1 to 6 carbon atoms;
- T1 and T2, individually, are selected from the group consisting of H and a linear or branched alkyl radical having 1 to 6 carbon atoms,
- and R2 is selected from the group consisting of a linear or branched alkyl, an alkyl substituted with one or more double or triple bonds, or with one or more aromatic groups;
- b) amides of formula (I), in which R1, is an aromatic heterocycle, Q, T1, T2 and n are as defined above, and R2 is as defined above, provided it is different from an aromatic group;
- c) amides of formula (I), in which Q is a C1-C6 alkyl and R1, R2, T1, T2 and n are as defined above for formula (I).
6 more elements
Dependencies are inferred from the claim text.