Cobalt-porphyrin complexes and use thereof as an anti-obesity agent
AssigneeMitoKor
InventorsTomas R. Szabo, Soumitra S. Ghosh, Robert E. Davis
Life of this patent
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Abstract
Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.
Claims62
A cobalt-porphyrin complex having the structure:
- 43
- or a salt thereof, wherein:
- R1 and R2 are the same or different and independently —(CH2)n—A—R5, wherein A is —C(═O)O—, —OC(═O)—, —C(═O)N(R)—, —N(R)C(═O)—, —C(═O)—, —N(R)—, —O— or —S—, and R is hydrogen, alkyl, substituted alkyl, arylalkyl, or substituted arylalkyl, and n is 2 or 3;
- R3 and R4 are the same or different and independently —CH═CH2 or —CH2CH3;
- R5 is, at each occurrence, the same or different and independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl or substituted arylalkyl;
- and
- L1 and L2 are optional ligands;
- and with the proviso that the cobalt-porphyrin complex of structure (I) has no more than 5% of the redox activity of cobalt mesoporphyrin.
A method for treating obesity, comprising administering an effective amount of a composition comprising a cobalt-porphyrin complex and a pharmaceutically acceptable carrier, wherein the cobalt-porphyrin complex has the structure:
- 44
- or a salt thereof, wherein:
- R1 and R2 are the same or different and independently —(CH2)n—A—R5, wherein A is —C(═O)O—, —OC(═O)—, —C(═O)N(R)—, —N(R)C(═O)—, —C(═O)—, —O— or —S—, and R is hydrogen, alkyl, substituted alkyl, arylalkyl, or substituted arylalkyl, and n is 2 or 3;
- R3 and R4 are the same or different and independently —CH═CH2 or —CH2CH3;
- R5 is, at each occurrence, the same or different and independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl or substituted arylalkyl;
- and
- L1 and L2 are optional ligands;
- and with the proviso that the cobalt-porphyrin complex of structure (I) has no more than 50% of the redox activity of cobalt mesoporphyrin.
Dependencies are inferred from the claim text.