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US 2002/0165207 A1Published application
Compositions and methods for the treatment of diabetic neuropathy
OwnerRichard Rosenbloominventor
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OwnerRichard Rosenbloominventor
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Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.
A composition for the treatment of diabetic neuropathy by a method of administration selected from the group consisting of oral administration, parenteral administration and inhalation, the compositions comprising a mixture of an amount of a compound that promotes synthesis of nerve growth factor which is effective when administration in the composition to promote synthesis of nerve growth factor, an amount of an aldose reductase inhibitor which is effective when administered in the composition to inhibit aldose reductase and an effective amount of an antioxidant.
A method for the treatment of diabetic neuropathy comprises the step of administering by a method of administration selected from the group consisting of oral administration, parenteral administration and inhalation, an effective amount of a mixture which comprises an amount of a compound that promotes synthesis of nerve growth factor which is effective when administered in the composition to promote synthesis of nerve growth factor, an amount of an aldose reductase inhibitor which is effective when administered in the composition to inhibit aldose reductase and an effective amount of an antioxidant.
Dependencies are inferred from the claim text.