Polyalkylene oxide-modified phospholipid and production method thereof
AssigneeNof Corporation
InventorsKazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi
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Abstract
A polyalkylene oxide-modified phospholipid represented by formula (1) defined in the specification, has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight.
Claims36
A polyalkylene oxide-modified phospholipid represented by formula (1), which has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight:
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- wherein R1CO and R2CO each independently represents an acyl group having from 4 to 24 carbon atoms;
- k represents from 1 to 6;
- R3O represents an oxyalkylene group having from 2 to 4 carbon atoms;
- n is a mean addition mol number of the oxyalkylene group having from 2 to 4 carbon atoms, and represents a number of from 10 to 800;
- M represents a hydrogen atom, sodium, or potassium;
- X represents a divalent hydrocarbon group having from 1 to 3 carbon atoms or —C(═O)(CH2)q—, wherein q represents from 1 to 4;
- p represents 0 or 1;
- and when p is 0, Y is a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, and when p is 1, Y is a hydrogen atom, an amino group, a carboxyl group, an aldehyde group, a glycidyl group, or a thiol group.
A method of producing a polyalkylene oxide-modified phospholipid, which comprises a process (A) of reacting an activated material of a polyalkylene oxide compound represented by formula (2) and a phospholipid represented by formula (3) in an organic solvent in the presence of an alkali metal salt whose aqueous solution shows alkalinity, the alkali metal salt being a solid salt not containing nitrogen,
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- wherein R3O represents an oxyalkylene group having from 2 to 4 carbon atoms;
- n is a mean addition mol number of the oxyalkylene group having from 2 to 4 carbon atoms, and represents a number of from 10 to 800;
- X represents a divalent hydrocarbon group having from 1 to 3 carbon atoms or —C(═O)(CH2)q—, q represents from 1 to 4;
- p represents 0 or 1;
- when p is 0, Y is a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, and when p is 1, Y is a hydrogen atom, an amino group, a carboxyl group, an aldehyde group, a glycidyl group, or a thiol group;
- and Z represents an activating group,
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- wherein R1CO and R2CO each independently represents an acyl group having from 4 to 24 carbon atoms and k represents from 1 to 6.
Dependencies are inferred from the claim text.