Carboplatin analogs for cancer treatment
AssigneeUnitech Pharmaceuticals, Inc.
InventorJiajiu Shaw
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Abstract
The synthesis and the use of a series of carboplatin analogs is disclosed. These carboplatin analogs may be represented by cis-Pt(II)L1L2, wherein each of L1 and L2, independently, is the carboxylate of phosphatidylserine, an α-amino acid, a β-amino acid, or a derivative thereof, wherein each ligand is bidentate with —NH2 and —COO− as the binding sites. The complexes can be used in the treatment of cancer.
Claims20
A complex with the formula cis-Pt(II)L1L2, wherein each of L1 and L2, independently, is the carboxylate of phosphatidylserine, the derivative of an α-amino acid, or the derivative of a β-amino acid, wherein each ligand is bidentate with —NH2 and —COO− as binding sites.
A method of treating cancer comprising administering to a cancer patient a therapeutically effective amount of a complex with the formula cis-Pt(II)L1L2, wherein each of L1 and L2, independently, is the carboxylate of phosphatidylserine, an (α-amino acid, a β-amino acid, the derivative of an α-amino acid, or the derivative of a β-amino acid, wherein each ligand is bidentate with —NH2 and —COO− as binding sites.
A pharmaceutical composition comprising:
- a) a pharmaceutically acceptable dosage form of a complex with the formula cis-Pt(II)L1L2, wherein each of L1 and L2, independently, is the carboxylate of phosphatidylserine, an α-amino acid, a β-amino acid, the derivative of an α-amino acid, or the derivative of a β-amino acid, wherein each ligand is bidentate with —NH2 and —COO− as binding sites;
- and
- b) a pharmaceutically acceptable buffer, solvent, or diluent.
A complex comprising ligands in free acid form with the formula cis-Pt(II)Cl2L3L4, cis-Pt(II)Br2L3L4 or cis-Pt(II)(NO3)2L3L4, wherein each of L3 and L4, independently is phosphatidylserine, an α-amino acid, a β-amino acid, a derivative of an α-amino acid, or the derivative of a β-amino acid, wherein each ligand is monodentate with —NH2 as a binding site.
Dependencies are inferred from the claim text.