Control of NK cell function and survival by modulation of ship activity
OwnerWilliam G. Kerr, Tomar Ghansahinventors
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Abstract
Inhibition of dendritic cell function in solid organ grafts or allogeneic bone marrow transplants prior to or during engraftment by blocking SH2-containing inositol phosphatase (SHIP) expression or function is taught as a method of abrogating immune rejection and thereby increasing the efficacy of engraftment of an allogeneic bone marrow transplant or solid organ allograft or xenograft. Also disclosed is a transgenic mouse having the genotype SHIP−/− which exhibits enhanced survival following mismatched allogeneic marrow grafts.
Claims11
A transgenic mouse, wherein the mouse has a genotype of SHIP−/−.
A method of abrogating immune rejection in solid organ grafts comprising:
- inhibiting dendritic cell function prior to or during engraftment, wherein said inhibiting is accomplished by blocking SHIP expression or function.
A method of inhibiting antigen presenting cell (APC) function before or during allogeneic transplants of solid organs, skin and bone marrow, comprising:
- blocking SHIP expression or function.
Dependencies are inferred from the claim text.