Process of making a compound by forming a polymer from a template drug
AssigneeMiRus LLC
InventorsJon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy, Paul M. Slattum, Lisa J. Hanson
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Abstract
A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
Claims27
A method of making a compound for delivery to a cell, comprising:
- forming a polymer in the presence of a biologically active drug.
A method of making a compound for delivery to a cell, comprising:
- a) cross-linking a polymer in the presence of a polyion, thereby forming a complex of polymer and polyion;
- and,
- b) delivering the complex to the cell.
A method of making a compound for delivery to a cell, comprising:
- modifying a molecule in the presence of the polyion thereby providing a deliverable polyion.
A monomer for forming a polymer having the general structure comprising:
- 19
- R is selected from the group consisting of a steric stabilizer and hydrogen;
- R′ is selected from the group consisting of a steric stabilizer and hydrogen;
- R″ is selected from the group consisting of a steric stabilizer and hydrogen;
- R′″ is selected from the group consisting of a steric stabilizer and hydrogen;
- a is selected from the group consisting of 1-20;
- b is selected from the group consisting of 1-20;
- c is selected from the group consisting of 1-20;
- and,
- X− consists of a monovalent anion.
A monomer for forming a polymer having the general structure comprising:
- 20
- wherein,
- R consists of protecting group 1;
- R′ consists of orthogonal protecting group 2;
- and,
- X− consists of monovalent anion.
A monomer for forming a polymer having the general structure comprising:
- 21
- R is selected from the group consisting of orthogonal protecting molecules 1, targeting molecules, steric stabilizers, and hydrogen;
- R′ is selected from the group consisting of orthogonal protecting molecules 2, targeting molecules, steric stabilization molecules, and hydrogen.
- a is selected from the group consisting of 1-20;
- b is selected from the group consisting of 1-20;
- c is selected from the group consisting of 1-20;
- d is selected from the group consisting of 1-20;
- and
- X− consists of a monovalent anion.
A method of making a compound for delivery to a cell, comprising:
- mixing a polyion with a first polymer and a second polymer thereby forming a deliverable complex.
Dependencies are inferred from the claim text.