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US 2002/0165177 A1Published application
Modified factor VIII cDNA
AssigneeAventis Behring GmbH, a German company
InventorsClaude Negrier, Jean Luc Plantier
Life of this patent
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Abstract
A modified Factor VIII cDNA is described in which the B-domain of the wild-type Factor VIII cDNA has been deleted and a truncated Factor IX intron 1 has been inserted in one or more locatons of the Factor VIII cDNA. Such modified Factor VIII cDNA may be used for a higher yield production of Factor VIII in vitro as well as in a transfervector for gene therapy.
Claims6
Modified Factor VIII cDNA, characterised in that the B-domain of the wild-type Factor VIII cDNA has been deleted and a truncated Factor IX intron 1 has been inserted in one or more locations of the Factor VIII cDNA.
Dependencies are inferred from the claim text.