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US 2002/0165171 A1Published application
Delivery construct for antisense nucleic acids and methods of use
AssigneeThe Johns Hopkins University School of Medicine
InventorHARRY C. DIETZ
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Abstract
A novel nucleic acid construct for delivery of antisense targeting sequences is provided. The construct includes intact stem loop structures and an antisense nucleic acid. Optionally, a ribozyme nucleic acid is included in the construct. The construct is useful for inhibition of selected genes in a cell. This allele-specific targeting is also useful in combination with replacement gene therapy.
Claims15
A nucleic acid construct for suppressing gene expression comprising:
- a 5′ stem loop structure;
- an antisense nucleic acid;
- and
- a 3′ stem loop structure.
1 more element
Dependencies are inferred from the claim text.