Therapeutic agent of osteoporosis comprising an active ingredient of quercetin derivatives
OwnerChung-Sook Kim, Hye-Kyung Ha +1inventors
InventorsChung-Sook Kim, Hye-Kyung Ha, Kye-Yong Song
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Abstract
The present invention relates to a therapeutic agent for osteoporosis which comprises an active ingredient of quercetin derivatives. The quercetin derivatives of the invention can be practically applied for the treatment and prevention of osteoporosis, since they effectively inhibit osteoclast proliferation and stimulate osteoblast proliferation more than conventional therapeutic agents for osteoporosis, and increase trabecular bone area highly without changing hormone level in body and untoward effects on hematopoietic function and immune system.
Claims15
A therapeutic agent for osteoporosis comprising an active ingredient of quercetin derivatives represented by the following general formula (I) and a pharmaceutically acceptable carrier:
- 3
- wherein,
- R1 is gentiotriose, glucopyranose, O-arabinofuranose, O-diglucopyranose, O-galactopyranose, O-galactoside-gallate, O-gentiobiose, O-glucopyranose, O-glucuronide, O-neohesperidose, O-rhamnopyranose, O-rutinose, O-sophorose, O-xylopyranose, OCH3, OH, rhamnogentiobiose, rhamnoglucose or sulfate;
- R2 is OH or O-glucopyranose;
- R3 is OCH3, OH, O-glucopyranose, O-glucuronopyranose or glucopyranose;
- R4 is OCH3 or OH;
- and,
- R5 is OCH3, OH, O-glucopyranose or O-glucose.
Dependencies are inferred from the claim text.