Compounds and methods for the modulation of CD154
AssigneesCbr, Millenium Pharmaceuticals, Inc.
InventorsYibing Yan, David Phillips, Lisa Alaimo, Patrick Andre, Veronica Alves
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Abstract
The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved in an inflammatory response. The present invention also relates to methods useful for identifying such compounds. The present invention also relates to the treatment of platelets for transfusion with metalloproteinase inhibitors to treat or prevent inflammation. The present invention also includes compositions and methods to treat injury and disease related to such biological processes.
Claims49
A method for the treatment of thrombosis in a subject comprising the administration of a CD154 inhibitor in an amount effective to inhibit the release of soluble CD154 (sCD154) from a platelet.
A method for the prevention or treatment of an inflammatory disorder in a subject comprising administering a CD154 inhibitor in an amount effective to inhibit the release of soluble CD154 from a platelet.
A method of inhibiting the release of soluble CD154 from a platelet sample, comprising incubating the platelets in a container with an effective amount of a CD154 inhibitor.
A container comprising a CD154 inhibitor.
A container comprising at least one agent which blocks platelet aggregation or which enhances thrombolysis.
Dependencies are inferred from the claim text.