Apo-2LI and Apo-3 polypeptides
AssigneeGenentech, Inc.
InventorAvi J. Ashkenazi
Life of this patent
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Abstract
Novel polypeptides, designated Apo-3 and Apo-2LI, involved in apoptosis are provided. Compositions including chimeric molecules, nucleic acids, and antibodies are also provided.
Claims45
Isolated biologically active Apo-2LI having at least about 80% sequence identity with native sequence Apo-2LI having amino acid residues 1 to 181 of SEQ ID NO:1.
Isolated Apo-2LI comprising amino acid residues 1 to 181 of SEQ ID NO:1.
A dimer molecule comprising a first Apo-2LI and a second Apo-2LI.
An antibody which binds to Apo-2LI.
Isolated nucleic acid encoding Apo-2LI.
An article of manufacture, comprising:
- a container;
- a label on said container;
- and
- a composition contained within said container, said composition comprising Apo-2LI.
Isolated biologically active Apo-3 polypeptide having at least about 80% sequence identity with native sequence Apo-3 having amino acid residues 1 to 417 of SEQ ID NO:6.
Isolated native sequence Apo-3 comprising amino acid residues 1 to 417 of SEQ ID NO:6.
Isolated biologically active polypeptide having at least about 80% sequence identity with the extracellular domain sequence of Apo-3 having amino acid residues 1 to 198 of SEQ ID NO:6.
Isolated extracellular domain sequence of Apo-3 comprising amino acid residues 1 to 198 of SEQ ID NO:6.
Isolated death domain sequence of Apo-3 comprising amino acid residues 338 to 417 of SEQ ID NO:6.
A non-human, transgenic animal which contains cells that express nucleic acid encoding Apo-3.
A non-human, knockout animal which contains cells having an altered gene encoding Apo-3.
An article of manufacture, comprising a container and a composition contained within said container, wherein the composition includes Apo-3 polypeptide or Apo-3 antibodies.
Dependencies are inferred from the claim text.