14089, a novel human trypsin serine protease and uses thereof
OwnerRosana Kapeller-Libermanninventor
Life of this patent
Estimating the term…
Abstract
The invention provides isolated nucleic acids molecules, designated 14089 nucleic acid molecules, which encode novel trypsin serine protease members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14089 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14089 gene has been introduced or disrupted. The invention still further provides isolated 14089 proteins, fusion proteins, antigenic peptides and anti-14089 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Claims20
An isolated nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid comprising the nucleotide sequence of SEQ ID NO:1, SEQ ID NO;3, or a complement thereof;
- and
- b) a nucleic acid molecule that encodes a polypeptide comprising the amino acid sequence of SEQ ID NO;2.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2.
A method of inhibiting an aberrant activity of a 14089-expressing cell, comprising contacting the cell with an antibody that modulates the activity of a 14089 polypeptide, in an amount that is effective to reduce or inhibit the aberrant activity of the cell.
A method of treating or preventing a disorder characterized by the cellular proliferation of a 14089-expressing cell in a subject, comprising administering to the subject an effective amount of an antibody that modulates the activity or expression of a 14089 polypeptide, such that the cellular proliferation of the 14089-expressing cell is reduced or inhibited.
Dependencies are inferred from the claim text.