Secreted proteins
OwnerKenneth Jacobs, John M. McCoy +10inventors
InventorsKenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, Maurice Treacy, Cheryl Evans, Michael J. Agostino, Zhijian Lu, David Merberg, Kei Tashiro, Tomoyuki Nakamura, Tasuku Honjo
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Abstract
Novel proteins and methods of treatment using same are disclosed.
Claims12
A composition comprising an isolated protein encoded by a polynucleotide selected from the group consisting of:
- (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1;
- (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 186 to nucleotide 1532;
- (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 261 to nucleotide 1532;
- (d) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 255 to nucleotide 1532;
- (e) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone AK647 deposited under accession number ATCC 98026;
- (f) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone AK647 deposited under accession number ATCC 98026;
- (g) a polynucleotide comprising the nucleotide sequence of the mature protein coding sequence of clone AK647 deposited under accession number ATCC 98026;
- (h) a polynucleotide encoding the mature protein encoded by the cDNA insert of clone AK647 deposited under accession number ATCC 98026;
- (i) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:2;
- (j) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:2 from amino acid 24 to amino acid 448;
- (k) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:2 from amino acid 26 to amino acid 448;
- (l) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID. NO:2 having biological activity;
- (m) a polynucleotide which is an allelic variant of a polynucleotide of any of (a)-(h) above;
- and
- (n) a polynucleotide which encodes a species homologue of the protein of any of (i)-(k) above.
A composition comprising a protein, wherein said protein comprises an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of SEQ ID NO:2;
- (b) the amino acid sequence of SEQ ID NO:2 from amino acid 1 to amino acid 104;
- (c) the amino acid sequence of SEQ ID NO:2 from amino acid 1 to amino acid 93;
- (d) the amino acid sequence of SEQ ID NO:2 from amino acid 24 to amino acid 448;
- (e) the amino acid sequence of SEQ ID NO:2 from amino acid 26 to amino acid 448;
- (f) fragments of the amino acid sequence of SEQ ID NO:2;
- and
- (g) the amino acid sequence encoded by the cDNA insert of clone AK647 deposited under accession number ATCC 98026;
- the protein being substantially free from other mammalian proteins.
A method for promoting smooth muscle cell growth or vasculogenesis which comprises administering to a mammalian subject a therapeutically effetic amount of an antibody of claim 11.
A method for promoting smooth muscle cell growth or vasculogenesis which comprises administering to a mammalian subject a therapeutically effetic amount of an antibody of claim 12.
Dependencies are inferred from the claim text.