Back to results
US 2002/0165140 A1Published application
Screening methods
AssigneeAngioGenetics Sweden AB
InventorsAnders Berkenstam, Goran Bertilsson, Lorenz Poellinger
Life of this patent
Estimating the term…
Abstract
The present invention relates a mammalian polypeptide designated Inhibitory PAS Domain Protein (IPAS) which polypeptide is useful for the inhibition of angiogenesis and/or tumor progression. The invention also relates to screening methods for compounds potentially useful as medicaments for the treatment of medical conditions related to angiogenesis or tumor progression.
Claims14
An isolated nucleic acid molecule selected from:
- (a) nucleic acid molecules comprising a nucleotide sequence set forth as SEQ ID NO:
- 2;
- (b) nucleic acid molecules comprising a nucleotide sequence capable of hybridizing, under stringent hybridization conditions, to a nucleotide sequence complementary the polypeptide coding region of a nucleic acid molecule as defined in (a) and which codes for a biologically active mammalian IPAS polypeptide or a functionally equivalent modified form thereof;
- and
- (c) nucleic acid molecules comprising a nucleic acid sequence which is degenerate as a result of the genetic code to a nucleotide sequence as defined in (a) or (b) and which codes for a biologically active mammalian IPAS polypeptide or a functionally equivalent modified form thereof:
2 more elements
Dependencies are inferred from the claim text.