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US 2002/0165138 A1Published application
Compositions and methods for the treatment of sepsis
AssigneeThe Regents of the University of Michigan
InventorsPeter A. Ward, Markus Huber-Lang, Vidya Sarma, Boris Czermak
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Abstract
The present invention relates to compositions and methods for the prevention and treatment of blood-borne and toxin mediated diseases, and in particular anti-C5a antibodies for the prevention and treatment of sepsis in humans as well as other animals. The present invention also relates to methods of generating anti-C5a antibodies employing C-terminal truncated C5a peptides.
Claims11
A composition comprising an isolated and purified peptide defined by an amino acid sequence selected from the group of SEQ ID NO:
- 14 and SEQ ID NO:
- 15, and portions thereof.
A method, comprising:
- a) providing;
- i) neutrophils,
- ii) a purified peptide having an amino acid sequence selected from the group of SEQ ID NO:
- 14 and SEQ ID NO:
- 15, and portions thereof;
- and
- b) mixing said neutrophils with said peptide under conditions such that the ability of said neutrophils to bind full-length human C5a peptide is reduced.
4 more elements
A method, comprising:
- a) providing;
- i) neutrophils,
- ii) a purified peptide having an amino acid sequence selected from the group of SEQ ID NO:
- 14 and SEQ ID NO:
- 15, and portions thereof;
- and
- b) treating said neutrophils with said peptide under such conditions that C5a activation of said neutrophils is inhibited.
4 more elements
Dependencies are inferred from the claim text.