Pharmaceutical compositions containing cyclosporins
OwnerFriedrich Richter, Jacky Vonderscherinventors
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Abstract
A pharmaceutical composition in the form of an emulsion preconcentrate for oral administration and containing a cyclosporin. The pharmaceutical composition has a carrier medium for the cyclosporin that contains a hydrophilic organic solvent; a mixed mono-, di-, and tri-glyceride or a transesterified and polyethoxylated vegetable oil; and a polyoxyethylene-sorbitan-fatty acid ester surfactant. The pharmaceutical composition provides high bioavailability and low inter- and intra-subject variability.
Claims16
A pharmaceutical composition in the form of an emulsion preconcentrate and comprising a cyclosporin in a carrier medium, the carrier medium comprising:
- 1) a hydrophilic organic solvent, 2) (a) mixed mono-, di-, and tri-glyceride or (b) a transesterified and polyethoxylated vegetable oil, and 3) a polyoxyethylene-sorbitan-fatty acid ester surfactant.
A pharmaceutical composition in the form of an emulsion preconcentrate and comprising from about 7.5 to about 15% by weight of a cyclosporin in a carrier medium, the carrier medium comprising:
- 1) about 15 to about 30% by weight of the carrier medium of a mixture of 1,2-propylene glycol and ethanol, 2) about 20 to 35% by weight of the carrier medium of a mixed mono-, di-, and tri-glyceride comprising about 0.2% free glycerol;
- about 32 to 36% mono-glycerides;
- about 46 to 48% di-glycerides;
- about 12 to 15% tri-glycerides;
- and about 1% free oleic acid, based on the weight of component (2), and 3) from about 30 to about 60% by weight of the carrier medium of a polyoxyethylene-sorbitan-fatty acid ester surfactant.
Dependencies are inferred from the claim text.