Methods for treating insulin resistance and identifying patients at risk for the disease
AssigneeSuperGen, Inc.
InventorFred I. Chasalow
Life of this patent
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Abstract
The present invention is directed to compositions and methods for treating insulin resistance and for ameliorating pathological conditions associated with insulin resistance. Also disclosed are methods for identifying patients at risk for developing non-insulin dependent diabetes melitis or insulin resistance. Also disclosed are methods for identifying patients at risk for developing or suffering from reactive hypoglycemia and methods of treatment thereof.
Claims21
A method for treating insulin resistance in a patient in need of such treatment, comprising the steps of:
- (a) determining the amount of IGF-2 in the serum of said patient;
- and
- (b) lowering the concentration of IGF-2 in the serum of said patient.
A method for treating insulin resistance in a patient in need of such treatment, comprising administering human 20K-GH, or a pharmacologically active variant or derivative thereof, in an amount and for a time sufficient to reduce the concentration of IGF-2 in the serum of said patient.
A method for treating insulin resistance in a patient in need of such treatment, comprising administering to said patient antibodies specific to human 20K-GH, wherein said antibodies stabilize 20K-GH in the circulation and wherein said antibodies are administered in an amount and for a time sufficient to reduce the concentration of IGF-2 in the serum of said patient.
A method for identifying a patient at risk for developing insulin resistance comprising the steps of:
- (a) determining the amount of 20K-GH in said patients serum;
- and
- (b) comparing the amount of 20K-GH in said patients serum with the amount of 20K-GH present in age and sex matched control serum,
- wherein said patient is at risk for developing insulin resistance if the amount of 20K-GH is significantly lower than the amount of 20K-GH present in said control.
A method for identifying a patient at risk for developing insulin resistance comprising the steps of:
- (a) determining the amount of IGF-2 in said patients serum;
- and
- (b) comparing the amount of IGF-2 in said patients serum with the amount of IGF-2 present in age and sex matched control serum,
- wherein said patient is at risk for developing insulin resistance if the amount of IGF-2 is significantly higher than the amount of IGF-2 present in said control serum.
A method for identifying a patient at risk for developing or suffering from reactive hypoglycemia comprising the steps of
- a) determining the amount of IGF-2 present in said patent's serum;
- and
- b) comparing the amount of IGF-2 in said patient's serum with the amount of IGF-2 present in age and sex matched control serum
- wherein said patient is at risk for developing or is suffering from reactive hypoglycemia if the amount of IGF-2 in said patient's serum is significantly lower than the amount of IGF-2 present in said control serum.
A method for treating a patient suffering from reactive hypoglycemia, comprising administering to a patient in need of such treatment, an agent selected from the group consisting of 22K-GH, a pharmacologically active variant or derivative thereof in an amount and for a time sufficient to increase the concentration of IGF-2 in the serum of said patient.
A method for treating a patient suffering from insulin resistance comprising administering to a patient in need of such treatment an effective amount for treating insulin resistance of 20K growth hormone.
Dependencies are inferred from the claim text.