Method and compositions for the treatment or amelioration of female sexual dysfunction
OwnerJeremy P. W. Heaton, Michael A. Adamsinventors
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OwnerJeremy P. W. Heaton, Michael A. Adamsinventors
Estimating the term…
The present invention provide a method of treating sexual dysfunction in a female, including the vasculogenic symptoms of delayed vaginal engorgement, diminished vaginal lubrication, pain or discomfort with intercourse (dyspareunia), diminished vaginal sensation, diminished vaginal orgasm, diminished clitoral sensation or diminished clitoral orgasm, or of combating vaginal pain by stimulating peripheral pelvic nerve release of nitric oxide (NO). The method comprises administering to a female in need of such treatment a therapeutically effective amount of a compound which acts on a mid-brain pathway to increase blood flow to the ilio-hypogastric-pudendal artery bed and stimulate the release of nitric oxide (NO) from peripheral NANC nerve cells. The preferred compound for the method of this invention is apomorphine or one of its pharmaceutically acceptable salts, esters, or pro-drugs.
A method of treating vasculogenic sexual dysfunction in a female mammal in need of such treatment which comprises administering to said female a therapeutically effective amount of a compound which acts upon a mid-brain pathway to increase blood flow in the ilio-hypogastric-pudendal arterial bed.
A method of treating vasculogenic sexual dysfunction in a female in need of such treatment which comprises administering to a patient in need of such treatment a therapeutically effective amount of apomorphine of a pharmaceutically acceptable salt, ester, or pro-drug thereof.
A method of inducing effective vasocon-strictive arousal in a female in need of such treatment comprising administering a therapeutically effective amount of apomorphine or a pharmaceutically effective salt, ester, or pro-drug thereof.
A method of treating vaginal engorgement insufficiency in a female in need of such treatment comprising administering a therapeutically effective amount of apomorphine or a pharmaceutically acceptable salt, ester or pro-drug thereof.
A method of treating clitoral erectile insufficiency in a female in need of such treatment comprising administering a therapeutically effective amount of apomorphine or a pharmaceutically acceptable salt, ester or pro-drug thereof.
A method of combating vaginal pain comprising administering to a female in need of such treatment a compound which acts upon mid-brain neural pathways to stimulate peripheral pelvic non-adrenergic non-cholinergic (NANC) nerve cell release of nitric oxide (NO).
A method of treating vaginal pain in a female in need of such treatment which comprises administering to a patient in need of such treatment a therapeutically effective amount of apomorphine of a pharmaceutically acceptable salt, ester, or pro-drug thereof.
A method of treating dyspareunia in a female in need of such treatment comprising administering a therapeutically effective amount of apomorphine or a pharmaceutically acceptable salt, ester, or pro-drug thereof.
Dependencies are inferred from the claim text.