Human cord blood derived unrestricted somatic stem cells (USSC)
AssigneeKourion Therapeutics GmbH
InventorPeter Wernet
Life of this patent
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Abstract
A composition in human cord and placental blood which comprises unrestricted somatic stem cells is described here which can be amplified in vitro to large quantities sufficient for medical applications as regenerative medicines. Initiation and maintenance as well as ex vivo expansion protocols of such stem cells from cord blood is described. Furthermore, it is shown that from these cells employing varying differentiation induction protocols distinct lineage progenitors for hematopoiesis and endothel, as well as mesenchymal progenitors for muscle bone, cartilage and fat as well as neural progenitors can be cultured and expanded for use in regenerative medicine.
Claims13
Unrestricted somatic stem cell (USSC) derived from human umbilical cord blood, placental blood and/or blood samples from new-borns, said somatic stem cell being distinct from but capable to differentiate into mesenchymal stem or progenitor cells, haematopoietic lineage stem or progenitor cells, neural stem or progenitor cells or endothelial stem or progenitor cells.
Somatic stem cells clearly distinguishable from mesenchymal stem cells based on tissue source for isolation and surface antigen expression patterns (HLA I) as well as by transcription factors.
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