32144, a novel human fatty acid amide hydrolase family member and uses thereof
OwnerRory A.J. Curtis, Kyle J. MacBeth +1inventors
InventorsRory A.J. Curtis, Kyle J. MacBeth, Laura A. Rudolph-Owen
Life of this patent
Estimating the term…
Abstract
The invention provides isolated nucleic acids molecules, designated 32144 nucleic acid molecules, which encode novel fatty acid amide hydrolase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32144 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32144 gene has been introduced or disrupted. The invention still further provides isolated 32144 proteins, fusion proteins, antigenic peptides and anti-32144 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Claims25
An isolated nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid comprising the nucleotide sequence of SEQ ID NO:1, SEQ ID NO:3, or a complement thereof;
- and
- b) a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2.
A method of inhibiting an aberrant activity of a 32144-expressing cell, comprising contacting the cell with an antibody that modulates the activity of a 32144 polypeptide, in an amount that is effective to reduce or inhibit the aberrant activity of the cell.
A method of treating or preventing a disorder characterized by the cellular proliferation of a 32144-expressing cell in a subject, wherein said disorder is a lung, colon, breast, or ovarian cancer, the method comprising administering to the subject an effective amount of an antibody that modulates the activity or expression of a 32144 polypeptide, such that the cellular proliferation of the 32144-expressing cell is reduced or inhibited.
Dependencies are inferred from the claim text.