57406, a novel human metalloprotease family member and uses thereof
OwnerRajasekhar Bandaruinventor
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Abstract
The invention provides isolated nucleic acids molecules, designated 57406 nucleic acid molecules, which encode novel metalloprotease members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 57406 nucleic acid molecules, host cells into that the expression vectors have been introduced, and nonhuman transgenic animals in that a 57406 gene has been introduced or disrupted. The invention still further provides isolated 57406 proteins, fusion proteins, antigenic peptides and anti-57406 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Claims24
An isolated nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 1, SEQ ID NO:3, or a complement thereof;
- and
- b) a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2.
A method of inhibiting an aberrant activity of a 57406-expressing cell, comprising contacting the cell with an antibody that modulates the activity of a 57406 polypeptide, in an amount that is effective to reduce or inhibit the aberrant activity of the cell.
A method of treating or preventing a disorder characterized by aberrant activity of a 57406 polypeptide, in a subject, comprising administering to the subject an effective amount of an antibody that modulates the activity or expression of a 57406 polypeptide, such that the disorder is treated.
A method for identifying an agent that modulates the activity or expression of a 57406 polypeptide or nucleic acid, comprising contacting the 57406 polypeptide or nucleic acid with an agent, and determining the effect of the agent on the activity or expression of the polypeptide or nucleic acid.
Dependencies are inferred from the claim text.