Transmembrane polypeptide expressed by lymphocytes
AssigneeZymoGenetics, Inc.
InventorsPaul O. Sheppard, Betty A. Haldeman, Richard D. Holly
Life of this patent
Estimating the term…
Abstract
White blood cells protect the body by inactivating and destroying foreign agents, including tumor cells. The specificity of the immune response is mediated by lymphocytes. Lymphocytes express certain transmembrane proteins on their cell surfaces that distinguish between normal lymphocyte cell types, as well as between normal and cancerous cells. These lymphocyte “markers” are used for diagnosis, prognosis, and therapy. Zsig16 is a new transmembrane protein that is expressed by human peripheral blood lymphocytes.
Claims22
An isolated polypeptide comprising an extracellular domain, wherein the extracellular domain comprises amino acid residues 19 to 47 of the amino acid sequence of SEQ ID NO:
- 2.
An isolated polypeptide, comprising an amino acid sequence which shares a percent identity with a reference amino acid sequence selected from the group consisting of amino acid residues 19 to 47 of SEQ ID NO:
- 2, amino acid residues 48 to 70 of SEQ ID NO:
- 2, and amino acid residues 71 to 92 of SEQ ID NO:
- 2, wherein the percent identity is selected from the group consisting of at least 70% identity, at least 80% identity, at least 90% identity, at least 95% identity, or greater than 95% identity, and wherein any difference between the amino acid sequence of the isolated polypeptide and the reference amino acid sequence is due to one or more conservative amino acid substitutions.
An isolated nucleic acid molecule that encodes a Zigl16 polypeptide, wherein the nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:
- 3, and (b) a nucleic acid molecule that hybridizes under stringent conditions to a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:
- 1, or the complement of SEQ ID NO:
- 1.
A fusion protein, comprising amino acid residues 19 to 47 of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.