Compositions and methods for regulating autolytic processes in bacteria
AssigneeTrustees of Dartmouth College
InventorAmbrose Cheung
Life of this patent
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Abstract
A nucleic acid sequence required for regulating the autolytic activity of bacteria is provided. Also provided are polypeptides encoded by the gene or mutant gene as well as vector and host cells for expressing these polypeptides. Methods for identifying and using agents which interact with the gene or mutant gene or polypeptides encoded thereby to inhibit bacterial growth and infectivity are also provided.
Claims25
A nucleic acid sequence which regulates expression of polypeptides involved in autolytic processes in bacteria.
A nucleic acid sequence comprising SEQ ID NO:1 or SEQ ID NO:3.
A polypeptide encoded by the nucleic acid sequence of SEQ. ID NO:
- 1 or SEQ ID NO:3.
A polypeptide sequence comprising SEQ ID NO:
- 2 or SEQ ID NO:4.
A kit for identifying the presence of RAT polypeptides or comprising a means for analyzing a biological sample for the presence of a RAT polypeptide, whereby detection of a RAT polypeptide in the sample is indicative of the susceptibility to treatment for a bacterial infection.
A kit for identifying the presence of the RAT gene comprising a means for analyzing a biological sample for the presence of the RAT gene.
A kit for identifying the presence of RAT mutant polypeptides or comprising a means for analyzing a biological sample for the presence of a RAT mutant polypeptide, wherein detection of a RAT mutant polypeptide in the sample is indicative of the susceptibility to treatment for a bacterial infection.
A kit for identifying the presence of the RAT mutant gene comprising a means for analyzing a biological sample for the presence of the RAT mutant gene.
Dependencies are inferred from the claim text.