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US 2002/0164754 A1Published application
Compositions and methods for treatment of Toxoplasma gondii and other apicomplexans
OwnerDavid J. Bzik, Barbara Foxinventors
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Abstract
Pyrimidine auxotroph mutants of apicomplexans are provided which are mutated in one of six enzymes of the de novo pyrimidine biosynthesis pathway. Also provided are methods of protecting an animal against infection by apicomplexans by administering a pyrimidine auxotroph mutant and methods for screening for inhibitors of pyrimidine salvage enzymes in apicomplexans.
Claims8
An isolated nucleic acid sequence encoding carbamoyl phosphate synthase of T. gondii.
A pyrimidine auxotroph mutant of an apicomplexan wherein one of six enzymes of the de novo pyrimidine biosynthesis pathway of apicomplexans is mutated.
Dependencies are inferred from the claim text.