Cell death inhibitory protein
OwnerNobuhiro Morishima, Takehiko Shibatainventors
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Abstract
The present invention provides a protein which inhibits the activation of caspase-12 and uses of the protein. The present invention relates to a recombinant protein selected from the group consisting of the following (a) and (b): (a) a protein consisting of the amino acid sequence as shown in SEQ ID NO: 4 (b) a protein which consists of the amino acid sequence as shown in SEQ ID NO: 4 having deletion, substitution or addition of one or several amino acids and which inhibits the activation of caspase-12.
Claims18
An isolated protein consisting of the amino acid sequence as shown in SEQ ID NO:
- 2 from which amino acids from position 1 to position 81, from position 1 to position 88, from position 1 to position 90, or from position 1 to position 93 are deleted.
An isolated gene encoding a protein consisting of the amino acid sequence as shown in SEQ ED NO:
- 2 from which amino acids from position 1 to position 81, from position 1 to position 88, from position 1 to position 90, or from position 1 to position 93 are deleted.
A complex formed by the binding of a MAGE-3 protein and/or a truncated form thereof to caspase-12 or the precursor thereof.
A cell death inhibitor comprising a MAG3E-3 protein and/or a truncated form thereof as an active ingredient.
A therapeutic agent for cell death related diseases, comprising a MAGE-3 protein and/or a truncated form thereof as an active ingredient.
A method of inhibiting the activation of caspase-12, comprising binding a MAGE-3 protein or a truncated form thereof to caspase-12 or the precursor thereof.
A method of detecting anti-apoptotic activity in a tissue or cell, comprising treating said tissue or cell with an antibody which specifically recognizes a MAGE-3 protein or a truncated form thereof and detecting expression of said MAGE-3 protein or said truncated form in said tissue or cell, wherein detection of a high expression of said MAGE-3 protein or said truncated form thereof indicates that said tissue of cell has anti-apoptotic activity.
A method of detecting anti-apoptotic activity in a tissue or cell, comprising detecting the expression of an MRNA encoding a MAGE-3 protein or a truncated form thereof in said tissue or cell.
Dependencies are inferred from the claim text.